Identifying a Vulnerable Site

These images are derived from 3R2X.pdb
Spacefilled Version showing HA1 (dark magenta), HA2 (lighter magenta), and Designed Binding Protein (green)
Backbone Version showing HA1 (dark magenta), HA2 (lighter magenta), and Designed Binding Protein (green)
Spacefilled Image of Key Residues on HA2 in epitope region (trp21, ile45,thr41)
Backbone Image of Key Residues on HA2 in epitope region (trp21, ile45,thr41)
Closeup of the epitope region (trp21, ile45,thr41)
Hydrophobic grove for the target protein
Contact residues between HB36 and HA2 (Phe49, Met53, trp57, phe61 Met56, phe69) (orange)
Close up of contact residues between HB36 and HA2 (Phe49, Met53, trp57, phe61 Met56, phe69) (orange) showing yellow hydrophobic groove
Close up of contact residues between HB36 and HA2 highlighting hot spot residues (Phe49, Met53)(red orange) showing yellow hydrophobic groove
Asp47,Val60, asn64, residue engineered for greater binding ability...(asp47 with Ser47 ala 60 with val60,asn64 with Lys64) (blue)