Antibody CR6261 bound to Hemagglutinin

Model of Hemagglutinin (rose) with Antibody CR6261 Bound (green)(Derived from 3GBN.pdb)

The Two Subunits of Hemagglutinin

HA1 (Chain 1): Blanched Almond
HA2 (Chain 2): Red, Yellow, Blue, Light Blue

• A Helix (residues 38-58): Red
  
• CD Helix (residues 75-126): Yellow
  
• Connecting Loop (residues 59-74): Blue
  
• Remainder of Subunit (residues 1-37, 127-173): Light Sky Blue
  

Important Residues on Hemagglutinin

Important Residues on HA that interact with HCDR1 Residues Pro28, Phe29, Phe74

• HA1 Residues Val40, Leu42, Leu292: CPK
  
• HA2 Residues Thr49, Val52, Ile56: CPK
  

Important Residues on HA that interact with conserved hydrophobic tip of HCDR1 residues Ile53, Phe54, Tyr98

• HA1 Residues His18, His38: CPK
  
• HA2 Residues Trp21, Thr41, Ile45: CPK
  

Model of Antibody CR6261 and Its Important Residues and Loops

• Light chain: green
  
• Heavy Chain: lawn green
  
• Residues Pro28, Phe29, Ile53,Phe54,Phe74,Tyr98: CPK
  
• CDR Loops
  • Ala33-Ser25: pink
  • Ile52-Thr57: medium purple
  • Met96- val100: pale green
  • Asp72-Asp73: Orchid

Spacefill Model of Antibody CR6261 attached to HA