Hit "Start Prezi" to Learn the Story of Cholera & Then Explore Below the Interactive JMOL Image of the Cholera Toxin!
Cholera Toxin(based on 1XTC.pdb)
Three Main Structural Subunits
The Two Main Amino Acid Residues Primarily Responsible for Ganglioside Binding: Trp-88 and Gly-33
Disulfide Bonds Stabilizing the Original Structure and Must be Broken Before the A1 Subunit can Enter the Cell
The Only Part that Enters the Cell: A1 Subunit. Once Trp-88 and Gly-33 Bind to the Cell's Surface, the Disulfide Bonds Above Break and the A1 Subunit Passes Through the Lipid Bilayer into the cell
The Amino Acid Residues that Make Up the Active Site Responsible for Binding NAD
Arg-7: The Amino Acid that is Essential for ADP-ribosyl Transfer Activity
