Hydrocodon
(Converted Wikipedia SMILES)
The regions of hydrocodone(gold) that bind to the mu opiod receptor
This carbonyl oxygen (aqua) is one of the reasons hydrocodon has greater activity than morphine. See footnote #1 below.
Hydrocodon's binding sections shown in gold in wireframe style.
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Some Important References
1. Opiod Structure Activity Relationship. (2019). Slideshare.net. Retrieved 17 March 2019, from https://www.slideshare.net/sujisusanth/opiod-sar-48199676
2. Ellis, C. R., Kruhlak, N. L., Kim, M. T., Hawkins, E. G. and Stavitskaya, L. Ellis, C., Kruhlak, N., Kim, M., Hawkins, E., & Stavitskaya, L. (2018). Predicting opioid receptor binding affinity of pharmacologically unclassified designer substances using molecular docking. PLOS ONE, 13(5), e0197734.

Oxycodone (based on converted Wikipedia SMILES File)
Oxycodon's binding regions (gold) to the mu opioid receptor
The additional hydroxyl group in this location(blue green)increases the activity of oxycodone as compared to morphine (see footnote #1)
A wireframed model showing the active binding sites of oxycodone in gold.
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Fentanyl (based on Converted Wikipedia SMILES File)
Fentanyl's binding sites(gold) to the mu opioid receptor in spacefilled.
Fentanyl's binding sites (gold) to the mu opioid receptor in wireframe.

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