Aquaporin2 Mutant

(based on 4OJ2.pdb)

This pdb file contains a mutant form of AQP2. This enabled the scientists to show the carboxyl terminus more completely. However, no Cd+2 ions were trapped in the crystallization.
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These residues are critical for bonding to lysosomal trafficking regulator interacting protein 5
These residues are important in the positioning of the carboxyl terminus necessary for trafficking
These residues are important in the flexibility of the carboxyl terminus necessary for trafficking intracellular cAMP triggers phosphorylation at this serine residue which flags trafficking to apical membranes
These residueshold nterminus in place critical for trafficking
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Key mutations in the NPA region
Key mutation in the selectivity filter region
Pore Narrowing mutations
Critical Mutations in Glycosylation
Mutations with both of these residues also interfere with trafficking
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AQP2 tetramer

(based on 4NEF.pdb)

This model shows all four chains of the Aquaporin2 tetramer. Also represented are the important divalent bonding domains important in the trafficking of AQP2 to and from intracellular vesicles.
Use this box to restore back to a backbone model without specific residues selected.
These residues are critical for bonding to lysosomal trafficking regulator interacting protein 5
These residues are important in the positioning of the carboxyl terminus necessary for trafficking
These residues are important in the flexibility of the carboxyl terminus necessary for trafficking
These residues hold nterminus in place critical for trafficking. The Glu3 residue was not crystallized
These residues holding cadmium ions(in vitro)(in vivo, calcium is the critical cation) in place critical for trafficking. The Glu3 residue was not crystallized
Use this box to restore back to a backbone model without specific residues selected.
Key mutations in the NPA region
Key mutation in the selectivity filter region
Pore Narrowing mutations
Critical Mutations in Glycosylation
Mutations with both of these residues also interfere with trafficking
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