Hemagglutinin at high pH

(based on 5HMG.pdb)

Backbone structure of high pH hemaggluttin (Including HA1 and HA2)
Sialic acid bound to hemagglutinin Disulfide bonds connecting HA1 & HA2
Stabilizing forces holding subunits together..Yellow (nonpolar) Red(charged and polar)
HA1 peptides not directly involved in fusion
HA2 peptides directly involved in fusion Only HA2 peptides shown
HA2 color coded regions at high pH
A look at just the HA2 monomer at high pH
The only HA2 residues that have the same structure at high and low pH

Hemagglutinin at low pH

(based on 1HTM.pdb)

Backbone structure of hemaggluttin (including only fusion peptides HA2)
HA2 Fusion Peptides
HA2 color coded regions at low pH
A look at just the HA2 monomer at low pH
The only HA2 residues that have the same structure at high and low pH
Spin On for high pH Spin On for low pH
Spin Off for high pH Spin Off for low pH