The Jmol image is based on pdb file 1XKK

EGFR Spacefill

EGFR Backbone

EGFR Backbone with Lapatibin

Lapatibin Lapatibin in CpK colors

Residues (thr854 and met793) that form hydrogen bonds with Lapatinib

Residues (ala743 and leu844) that form hydrophobic bonds with Lapatinib

Residues forming pocket for 3'chloro-analine group

Residues forming pocket for 3-fluroobenzyloxy

Residues binding Lapatinib in place