Glycoprotein bound to its Endosomal Receptor Niemann-Pick C1
(based on 5F1B.pdb)
The model shown at startup shows the Ebola Glycoprotein attached to an Endosomal Receptor colored in cpk.
This model shows the prefusion state of the Ebola Glycoprotein in spacefill with GP1 olivedrab and GP2 colored in palegoldenrod.
The two subunits are shown in backbone, GP1 in olivedrab, and GP2 in palegoldenrod.
Focusing just on GP2
This space filled crystallization of the GP complex and the Niemann Pick crucial to the infection of EBOV shows primary amino acids shown in green that are epitopes of GP1 and the Niemann receptor which primes GP1 for entry, fusion, and transformation. By binding to the NPC-1 receptor, the internal fusion loop of GP1 is triggered to begin membrane fusion. The gold residues are noted as being important because of their hydrophobic nature, the red residues presumably form a salt bridge, and the cyan residues form an important hydrogen bond site.
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Glycoprotein and Ibuprofen:
Search for Antagonists
(based on 5JQB.pdb)
The model shown at startup shows the spacefilled Ebola glycoprotein interacting with ibuprofen, a painkiller.
This shows the pain reliever ibuprofen in yellow linked to the GP1(light blue)/GP2 (light green) complex
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