De Novo Protein Attachment to Hemagglutinin

Model of Hemagglutinin (rose) with De Novo Binding Protein Bound (blue)(Derived from 3R2X.pdb)

The Two Subunits of Hemagglutinin

HA1 (Chain 1): Blanched Almond
HA2 (Chain 2): Red, Yellow, Blue, Light Blue

Important Residues on Hemagglutinin

Important Residues on HA that interact with HCDR1 Residues Pro28, Phe29, Phe74

Important Residues on HA that interact with conserved hydrophobic tip of HCDR1 residues Ile53, Phe54, Tyr98

Backbone Model of De Novo Binding Protein HB36.3 and Its Important Residues

Spacefilled Model of De Novo Binding Protein HB36.3 and Its Important Residues

Spacefill Model of Antibody CR6261 attached to HA

Additional images showing the binding between hemagglutinin and the De Novo binding Protein HB36.3