SMART Team Investigations

 

"Misfiring"... Shutting down Mutant EGFR
(2008-09  SMART Team)

Summary
                     
Jmol Animations EGFR and RAS
                            EGFR & Lapatibin: a Chemotherapy
                            RAS and GTP:  A Site for Possible Signal Interference
                            Guanosine Phosphates... Important Signaling Agents
                     
EGFR Abstract
                                    Ras Abstract
 
3 PowerPoints Describing the Story
                         Controlling a Killer Malfunction
                              Cancer:  Modeling Different Methods to Control It

                              Controlling Cancer
SMART Team Members


      

Epidermal Growth Factor Receptor (EGFR)

 



RAS GTPase

 

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Background images are from pdb files downloaded from the Protein Data Bank.
http://www.rcsb.org/pdb/home/home.do

The images are of catalase, single stranded DNA, and of insulin. 
The pdb file numbers (Brookhaven Extension numbers) are 4BLC, 1EW1,  and 2CEU.